Louis-Félix Nothias

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland

Research associate, Phytochemistry and Bioactive Natural Products. 2021-2023.

Skaggs School of Pharmaceutical Sciences, University of California San Diego, La Jolla, USA

Post-doctoral researcher, Dorrestein Lab. 2015-2022.

Post-doctoral fellow, Marie Sklodowska-Curie Action Fellow H2020. 2017-2018.

Education

PhD, Organic Chemistry, Natural Products Research, University of Corsica, FR, 2015. Manuscript

Master, Chemistry applied to Phytochemistry, University of Corsica, FR, 2011. Manuscript

Bachelor, Chemistry, University of Corsica, FR, 2009.

Academic awards

Thesis Award, University of Corsica Ville Ajaccio, FR, 2015.

Thesis Award, Accademia Corsa, FR, 2015.

Best talk, Trends in Natural Products Research, Phytochemical Society of Europe, Austria, 2014.

Research Grants and Fellowships

Grants (not up-to-date)

Contract Research Agreement, California Research Alliance (CARA), Developement of Computational Metabolomics Pipeline. USD 200k. 2016.

Centre for Microbiome Innovation Support Program, UC San Diego, Metabolomics Application in Microbiome Research. USD 40k. 2016.

Fellowships

European Comission, Program H2020, Post Doctoral MSCA Fellowship, Exploring the Impact of Pesticide on the 3D Metabolome and the Microbiota from the Whole Plant to the Cell Scale. EUR 247k. 2017-2019.

UMR SPE CNRS, University of Corsica, France, PhD Fellowship, Contrat doctoral de Ecole Doctorale Environment et Societe. EUR 100k. 2011-2014.

Teachings (not up-to-date)

Université Cote d'Azur

Travaux pratiques en analyse de produits naturels (approx. 32h, yearly), Master 2023-26.

University of Geneva

Travaux pratiques en Phytochimie (approx. 100h, yearly), Pharmacognosie, 2021-22.

UC San Diego

Pathways to Scientific Teaching course, Participant (16h workshop), 2019.

University of Corsica, France

Stereochemistry and reactions, lecturer (50h) with Pr. Costa, 2011-2014. Undergrad students.

General Chemistry, lecturer (98h) with Pr. Muselli and Tomi, 2011-2014. Undergrad students.

Mentorship, Student's projects and chemical risk course (25h), 2011-2012. Undergrad students.

GNPS molecular networking, Organisor and trainer on GNPS, 2014-11.

Metabolomics Society Annual Meeting

GNPS and MS2LDA workshop, co-organisor and trainer on GNPS, 2019-05. For researchers.

GNPS web-platform online workshops

GNPS online workshops on Youtube, Training on molecular networking, 2019-2020. For researchers.

Ceczh Academia of Sciences

GNPS and MS2LDA workshop, co-organisor and trainer on GNPS, 2019-06. For researchers.

Center for Computational Mass Spectrometry @UC Diego {#center-for-computational-mass-spectrometry-uc-diego}

CCMS Advanced School, Trainer on mass spectrometry processing, 2018-12. For researchers.

Center for Microbiome Initiative @UC San Diego {#center-for-microbiome-initiative-uc-san-diego}

2nd Workshop on Microbiome/Metabolomics Pipeline, Co-organisor and trainer on molecular networking annotation, 2017-01. For researchers.

1st Workshop on Microbiome/Metabolomics Pipeline, Co-organisor and trainer on molecular networking annotation, 2016-11. For researchers.

Presentations

Oral Conference Presentations

Bioactivity Based Molecular Networking for the Discovery of Drug Leads in Bioassay-Guided Fractionation. 66th ASMS Conference on Mass Spectrometry and Allied Topics. San Diego, USA, 2018.

3D-Plant2Cells Project: Exploring the Impact of Pesticide on Plant Metabolome and Microbiota. 9th Joint Natural Products Conference of ASP, GA, PSE, SIF, AFERTP, JSP.. Copenhaguen, Denmark, 2016.

3D Molecular Cartography of the Exposome and Metabolome of Fruits. 13th Annual Conference of the Metabolomics Society. Brisbane, Australia, 2017.

Welcoming green metabolomic: using supercritical fluid chromatography, mass spectrometry, and molecular networking to target bioactive compounds. 10st French Metabolomics Conference, RFMF.. Montpellier, France, 2016.

Accelerating Natural Products Research Workflow with Molecular Networking to Study Euphorbia Species. Meeting of the French Society for Mass Spectrometry, SMAP 2015. Ajaccio, France, 2015.

Studies of Euphorbia Species. 2nd AFERP-STOLON International Symposium. Lyon, France, 2015.

Antiviral Diterpenes from Corsican Euphorbia Species. Trends in NPR, a young scientist meeting of Phytochem. Soc. of Europe and OPhG. University of Innsbruck, Austria, 2013.

Invited Departmental Presentation

Studying the Antiviral Activity of Euphorbia Plant Extract using Molecular Networking. . Paris, 2016.

Selected Poster Conference Presentations

Feature Based Molecular Networking of Untargeted Mass Spectrometry Data with the GNPS web-platform. 67th ASMS Conference on Mass Spectrometry and Allied Topics. Atlanta, USA, 2015.

Feature Based Molecular Networking of Untargeted Mass Spectrometry Data with the GNPS web-platform. The 15th Conference of Metabolomics Society. The Haguen, Nederlands, 2015.

Participation

Dagstuhl seminar on computational metabolomics, 2017, 2020, 2022, 2024

Microbiome Movement seminar, 2018.

Ecole Thematique CNRS Natural Products, 2014.

Earth Microbiome Project, 2018-2020.

MicrobiomeSupport, 2018-2020.

MetaSpace, 2018.

3DMASSOMICS, 2016.

Membership

Metabolomics Society, American Society for Mass Spectrometry, RFMF, PSE.

Students

Anupriya Tripathi (PhD), contributed to mentoring with Prof. Dorrestein and Knight, Metabolome and Microbiome Data Analysis, 2018-2020.

Abinesh Sarvepalli (Undergrad), Integrating OpenMS and GNPS, 2018-2019.

Zheng Zhang (Undergrad), Integrating MZmine and GNPS, 2016-2017.

Melissa Esposito (PhD), Étude de la diversité structurale et des propriétés biologiques de diterpènes macrocycliques d'Euphorbia de Corse, 2016-2019.

Melissa Esposito (Master), Phytochemical Investigation of Euphorbia dendroides, 2015.

Reviewer

Nature Communications, Analytical Chemistry, Journal of Natural Products, Frontiers in Chemistry, Metabolites, Molecules.

Local talks

Deep Metabolome Analysis with IODA, 2019. Feature Based Molecular Networking for Advanced Metabolomics Data Analysis with GNPS, 2019. Can a Fungal Endophyte Modulate Host Metabolome, 2018. Improving molecular formula identification using Gibbs sampling on fragmentation trees, 2018. Bioactivity Based Molecular Networking for the Discovery of Drug Lead, 2018. Exploring the Influence of Pesticides on Plant Metabolome and Microbiota, 2017. FBMN Workflow for Holistic Metabolomics Analysis, 2016. Studying the Metabolome and Microbiome of Skin Psoriasis in 3D, 2016. Studying the Antiviral Activity of Euphorbia Plant Extracts, A Search for New Diterpenes with Biological Activities, 2016. Bibliographic Seminar on Computational Mass Spectrometry Tools for Natural Products Analysis, 2014.

Outreach

Social Media Video GNPS Youtube Channel. GNPS video tutorial and workshop. 2019.

Press release University of California San Diego. New workflow revolutionizes the discovery of candidate drugs from nature. 2016.

Press release Friedrich-Schiller-Universitaet Jena. Identifying compound classes through machine learning. 2020.

Press article In Corsica N10. L'Or Vert. 2016.

Publications (not-up-to-date)

Use Google Scholar for latest record.

Kelly, Linda Wegley, Craig E Nelson, Daniel Petras, Irina Koester, Zachary A Quinlan, Milou G.I. Arts, Louis-Felix Nothias, et al. 2021. "Distinguishing the Molecular Diversity and Energetic Potential of Exometabolites Produced by Macroalgae and Reef Building Corals." Proceedings of the National Academy of Sciences, under review.

Daniel, Petras, Rivera Sara, M. Stephens Brandon, Schwenk Sarah, Rabines Ariel, Schmid Robin, Louis-Felix Nothias, et al. 2021. "Community Metabolome Dynamics of a Phytoplankton Bloom in the California Current Ecosystem." In-Preparation.

Liu, Jingyu, Louis-Felix Nothias, Pieter C. Dorrestein, Kapil Tahlan, and Dawn R.D. Bignell. 2021. "Genomics and Metabolomics Analysis of the Potato Common Scab Pathogen Streptomyces Scabiei." In-Preparation.

Zuo, Zeyuan, Liu Cao, Louis-Felix Nothias*, and Hosein Mohimani. 2021. "MS2Planner Optimizing Coverage in Tandem Mass Spectrometry Based Metabolomics by Iterative Data Acquisition." In-Preparation.

Nothias-Esposito, Melissa, Anupriya Tripathi, Rob Knight, Pieter C. Dorrestein, and Louis-Felix Nothias*. 2021. "A Gradient Benchmark Dataset for Evaluating Ordination Methods in Nontargeted Metabolomics." In-Preparation.

Aron, Allegra T, Emily Gentry, Kerry L McPhail, Louis-Felix Nothias, Mélissa Nothias-Esposito, Amina Bouslimani, Daniel Petras, et al. 2020. "Reproducible Molecular Networking of Untargeted Mass Spectrometry Data Using Gnps." Nature Protocols. https://www.nature.com/articles/s41596-020-0317-5.

Nothias#, Louis-Felix, Daniel Petras#, Robin Schmid#, Kai Duhrkop, Johannes Rainer, Abinesh Sarvepalli, Ivan Protsyuk, et al. 2020. "Feature-Based Molecular Networking in the Gnps Analysis Environment." Nature Methods 7: 905--8. https://doi.org/10.1038/s41592-020-0933-6.

Mingxun, Wang, Alan K Jarmusch, Fernando Vargas, Alexander A Aksenov, Julia M Gauglitz, Kelly Weldon, Daniel Petras, et al. 2020. "Mass Spectrometry Searches Using Masst." Nature Biotechnology, 1--4. https://doi.org/10.1038/s41587-019-0375-9.

Reher, Raphael, Hyun Woo Kim, Chen Zhang, Huanru Henry Mao, Mingxun Wang, Louis-Felix Nothias, Andres Mauricio Caraballo-Rodriguez, et al. 2020. "A Convolutional Neural Network-Based Approach for the Rapid Characterization of Molecularly Diverse Natural Products." Journal of the American Chemical Society. https://doi.org/10.1021/jacs.9b13786.

Kang, Kyo Bin, Sunmin Woo, Madeleine Ernst, Justin JJ van der Hooft, Louis-Felix Nothias, Ricardo R da Silva, Pieter C Dorrestein, Sang Hyun Sung, and Mina Lee. 2020. "Assessing Specialized Metabolite Diversity of Alnus Species by a Digitized Lc--Ms/Ms Data Analysis Workflow." Phytochemistry 173: 112292. https://doi.org/10.3389/fpls.2019.00846.

Ludwig, Marcus, Louis-Felix Nothias, Kai Dührkop, Irina Koester, Markus Fleischauer, Martin A Hoffmann, Daniel Petras, et al. 2020. "Database-Independent Molecular Formula Annotation Using Gibbs Sampling Through Zodiac." Nature Machine Intelligence 2: 629--41. https://doi.org/10.1038/s42256-020-00234-6.

Aksenov, Alexander, Ivan Laponogov, Zheng Zhang, Sophie Doran, Ilaria Belluomo, Dennis Veselkov, Wout Bittremieux, et al. 2020. "Algorithmic Learning for Auto-Deconvolution of Gc-Ms Data to Enable Molecular Networking Within Gnps." Nature Biotechnology, in press. https://www.nature.com/articles/s41587-020-0700-3.

Jarmusch, Alan K, Mingxun Wang, Christine M Aceves, Rohit S Advani, Shaden Aguire, Alexander A Aksenov, Gajender Aleti, et al. 2020. "ReDU: A Framework to Find and Reanalyze Public Mass Spectrometry Data." Nature Methods 17 (9): 901--4. https://www.nature.com/articles/s41592-020-0916-7.

De la Torre, HE, R Jiménez, S Camarero, L Roman, JL Fernandez-García, M Beltran, Louis-Felix Nothias, et al. 2020. "4 Deoxyphorbol a Inhibits HIV1 Infection and Reactivates Viral Reservoirs Through PKC and MEK Activation and Synergizes with Vorinostat and Antiretroviral Drugs." Biochemical Pharmacology 177: 113937. https://www.sciencedirect.com/science/article/abs/pii/S0006295220301659.

Kai, Duhrkop, Nothias Louis-Felix, Ludwig Marcus, Fleischauer Markus, Hoffmann Martin, Rousu Juho, Dorrestein Pieter C., and Boecker Sebastian. 2020. "Comprehensive Classification of Unknowns Using Fragmentation Spectra." Nature Biotechnology, under review. https://www.nature.com/articles/s41587-020-0740-8.

Martin, Hoffmann, Nothias Louis-Felix, Ludwig Marcus, Duhrkop Kai, Fleischauer Markus, Gentry Emily, Meehan Michael, et al. 2020. "Flipping the Metabolomics Workflow, Assigning Confidence to Structure Annotations from Fragmentation Spectra with Cosmic." In Preparation.

Marcus, Ludwig, Broeckling Corey, Dorrestein Pieter C., Duhrkop Kai, Emma Schymanski, Boecker Sebastian, and Nothias* Louis-Felix. 2020. "Studying Charge Migration Fragmentation of Sodiated Precursor Ions in Collision-Induced Dissociation at the Library Scale." Journal of the American Society for Mass Spectrometry, in press. https://pubs.acs.org/doi/abs/10.1021/jasms.0c00240.

Schmid#, Robin, Daniel Petras#, Louis-Felix Nothias#, Wang Ming, Aron Allegra T., Korf Ansgar, Rainer Johannes, Garcia-Aloy Mar, Karst Uwe, and Dorrestein Pieter C. 2020. "Ion Identity Molecular Networking in the Gnps Environment." Nature Communications, under review. https://www.biorxiv.org/content/10.1101/2020.05.11.088948v1.

Louis-Felix, Nothias, Nakatsuji Teruaki, Bouslimani Amina, Chen Weixuan, Tripathi Anupriya, Wang Ming, R. Da Silva Ricardo, et al. 2020. "Molecular Cartography of Psoriasis Provides Evidence for a Role of the Endocannabinoids System in the Pathogenesis." In Preparation.

Xie, Hao-Fen, Ya-Shuai Kong, Ru-Ze Li, Louis-Felix Nothias, Hong Zhang, Lu-Lu Liu, Ting-Ting An, et al. 2020. "Feature-Based Molecular Networking Analysis of the Metabolites Produced by in Vitro Solid-State Fermentation Reveals Pathways for the Bioconversion of Epigallocatechin Gallate." J. Agric. Food Chem. 68: 7995--8007. https://pubs.acs.org/doi/abs/10.1021/acs.jafc.0c02983.

Kim Hyun, Woo, Mingxun Wang, Christopher Leber, Louis-Felix Nothias, Raphael Reher, Kyo Bin Kang, Justin JJ van der Hooft, et al. 2020. "NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products." ACS Central Science. https://http://10.0.103.66/chemrxiv.12885494.

Martin H, Christian, Roberto Ibanez, Louis-Felix Nothias, Andres Mauricio Caraballo-Rodriguez, Pieter C Dorrestein, Marcelino Gutierrez, and others. 2020. "Metabolites from Microbes Isolated from the Skin of the Panamanian Rocket Frog Colostethus Panamansis (Anura: Dendrobatidae)." Metabolites 10 (10): 406. https://www.mdpi.com/2218-1989/10/10/406.

Tripathi, Anupriya, Yoshiki Vazquez-Baeza, Julia M Gauglitz, Mingxun Wang, Kai Duhrkop, Melissa Esposito-Nothias, Deepa Acharya, et al. 2020. "Chemically-Informed Analyses of Metabolomics Mass Spectrometry Data with Qemistree." Nature Chemical Biology. https://www.nature.com/articles/s41589-020-00677-3.

Aluwihare, Lihini, Daniel Petras, Irina Koester, Louis-Felix Nothias, Marcus Ludwig, Kai Duhrkop, Mingxun Wang, Sebastian Bocker, and Pieter Dorrestein. 2020. "Challenges and Rewards of Nontargeted Studies of Marine Dissolved Organic Matter (Dom) Composition Using Liquid Chromatography Coupled to Tandem Mass Spectrometry, Case Studies from Coastal, Marine Environments." In Ocean Sciences Meeting 2020. AGU. https://agu.confex.com/agu/osm20/meetingapp.cgi/Paper/644927.

Mohimani, Hosein, Alexey Gurevich, Kelsey L Alexander, C Benjamin Naman, Tiago Leao, Evgenia Glukhov, Nathan A Moss, et al. 2019. "MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities." Cell Systems 9 (6): 600--608.e4. https://doi.org/10.1016/j.cels.2019.09.004.

Christian, Martin H., Ibáñez Roberto, Louis-Felix Nothias, Laura K Reinert, Louise A Rollins-Smith, Pieter C Dorrestein, Marcelino Gutiérrez, and others. 2019. "Viscosin-Like Lipopeptides from Frog Skin Bacteria Inhibit Aspergillus Fumigatus and Batrachochytrium Dendrobatidis Detected by Imaging Mass Spectrometry and Molecular Networking." Scientific Reports 9 (1): 1--11. https://doi.org/10.1038/s41598-019-39583-7.

Ernst, Madeleine, Kyo Bin Kang, Andrés Mauricio Caraballo-Rodríguez, Louis-Felix Nothias, Joe Wandy, Christopher Chen, Mingxun Wang, et al. 2019. "Molnetenhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools." Metabolites 9 (7): 144. https://doi.org/10.3390/metabo9070144.

Nothias-Esposito#, Mélissa, Louis-Felix Nothias#, Ricardo R Da Silva, Pascal Retailleau, Zheng Zhang, Pieter Leyssen, Fanny Roussi, et al. 2019. "Investigation of Premyrsinane and Myrsinane Esters in Euphorbia Cupanii and Euphobia Pithyusa with Ms2lda and Combinatorial Molecular Network Annotation Propagation." Journal of Natural Products 82 (6): 1459--70. https://doi.org/10.1021/acs.jnatprod.8b00916.

Ernst, Madeleine, Louis-Felix Nothias, Justin JJ van der Hooft, Ricardo Roberto Da Silva, C Haris Saslis-Lagoudakis, Olwen M Grace, Karen Martinez-Swatson, et al. 2019. "Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L." Frontiers in Plant Science 10: 846. https://doi.org/10.3389/fpls.2019.00846.

Bolyen, Evan, Jai Ram Rideout, Matthew R Dillon, Nicholas A Bokulich, Christian C Abnet, Gabriel A Al-Ghalith, Harriet Alexander, et al. 2019. "Reproducible, Interactive, Scalable and Extensible Microbiome Data Science Using Qiime 2." Nature Biotechnology 37 (8): 852--57. https://doi.org/10.1038/s41587-019-0252-6.

Shi, Da, Kirti Kandhwal Chahal, Patricia Oto, Louis-Felix Nothias, Anjan Debnath, James H McKerrow, Larissa M Podust, and Ruben Abagyan. 2019. "Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria Fowleri Sterol $\Delta$8- $\Delta$7-Isomerase and Phenotypic Assays." ACS Infectious Diseases 5 (12): 2029--38. https://doi.org/10.1021/acsinfecdis.9b00227.

AbuSara, Nader F, Brandon M Piercey, Marcus A Moore, Arshad A Shaikh, Louis-Felix Nothias, Santosh K Srivastava, Pablo Cruz-Morales, Pieter C Dorrestein, Francisco Barona-Gomez, and Kapil Tahlan. 2019. "Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-Producing Streptomyces Species Provides Insight into Specialized Metabolism." Frontiers in Microbiology 10: 2550. https://doi.org/10.3389/fmicb.2019.02550.

Morton, James T, Alexander A Aksenov, Louis-Felix Nothias, James R Foulds, Robert A Quinn, Michelle H Badri, Tami L Swenson, et al. 2019. "Learning Representations of Microbe--Metabolite Interactions." Nature Methods 16 (12): 1306--14. https://pubmed.ncbi.nlm.nih.gov/31686038/.

Protsyuk#, Ivan, Alexey V Melnik#, Louis-Felix Nothias#, Luca Rappez, Prasad Phapale, Alexander A Aksenov, Amina Bouslimani, Sergey Ryazanov, Pieter C Dorrestein, and Theodore Alexandrov. 2018. "3D Molecular Cartography Using Lc--Ms Facilitated by Optimus and 'Ili Software." Nature Protocols 13 (1): 134. https://doi.org/10.1038/nprot.2017.122.

Nothias#, Louis-Félix, Mélissa Nothias-Esposito#, Ricardo da Silva, Mingxun Wang, Ivan Protsyuk, Zheng Zhang, Abi Sarvepalli, et al. 2018. "Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation." Journal of Natural Products 81 (4): 758--67. https://doi.org/10.1021/acs.jnatprod.7b00737.

Nothias, Louis-Felix, Mauro Ballero, Andrea Maxia, Federica Pollastro, Pieter Dorrestein, Julien Paolini, Marc Litaudon, and Giovanni Appendino. 2018. "Chemodiversity or Taxonomy Error? A Search for the True Phytochemical Profile of Ferula Arrigonii Bocchieri." Phytochimie. openscience.fr/Phytochemistry.

Silva, Ricardo R da, Mingxun Wang, Louis-Felix Nothias, Justin JJ van der Hooft, Andrés Mauricio Caraballo-Rodríguez, Evan Fox, Marcy J Balunas, Jonathan L Klassen, Norberto Peporine Lopes, and Pieter C Dorrestein. 2018. "Propagating Annotations of Molecular Networks Using in Silico Fragmentation." PLoS Computational Biology 14 (4): e1006089. https://doi.org/10.1371/journal.pcbi.1006089.

Olivon#, Florent, Louis-Félix Nothias#, Vincent Dumontet, Pascal Retailleau, Sylvie Berger, Gilles Ferry, William Cohen, et al. 2018. "Natural Inhibitors of the Rhoa--P115 Complex from the Bark of Meiogyne Baillonii." Journal of Natural Products 81 (7): 1610--8. https://doi.org/10.1021/acs.jnatprod.8b00209.

Galtier d'Auriac, Ines, Robert A Quinn, Heather Maughan, Louis-Felix Nothias, Mark Little, Clifford A Kapono, Ana Cobian, et al. 2018. "Before Platelets: The Production of Platelet-Activating Factor During Growth and Stress in a Basal Marine Organism." Proceedings of the Royal Society B: Biological Sciences 285 (1884): 20181307. https://doi.org/10.1098/rspb.2018.1307.

Quinn, Robert A, William Comstock, Tianyu Zhang, James T Morton, Ricardo da Silva, Alda Tran, Alexander Aksenov, et al. 2018. "Niche Partitioning of a Pathogenic Microbiome Driven by Chemical Gradients." Science Advances 4 (9): eaau1908. https://doi.org/10.1126/sciadv.aau1908.

Mohimani, Hosein, Alexey Gurevich, Alexander Shlemov, Alla Mikheenko, Anton Korobeynikov, Liu Cao, Egor Shcherbin, Louis-Felix Nothias, Pieter C Dorrestein, and Pavel A Pevzner. 2018. "Dereplication of Microbial Metabolites Through Database Search of Mass Spectra." Nature Communications 9 (1): 1--12. https://doi.org/10.1038/s41467-018-06082-8.

Koester, Irina, Daniel Petras, John K. Brunson, Louis-Felix Nothias, Elizabeth Margot, Farooq Azam White, Rob Knight, Andrew E Allenand, Pieter Dorrestein, and Lihini Aluwihare. 2018. "A Metabolomic Profile of the Pseudo-Nitzschia Microbiome." In Ocean Sciences Meeting 2018. AGU. https://agu.confex.com/agu/os18/meetingapp.cgi/Paper/325797.

Mohimani, Hosein, Alexey Gurevich, Alla Mikheenko, Neha Garg, Louis-Felix Nothias, Akihiro Ninomiya, Kentaro Takada, Pieter C Dorrestein, and Pavel A Pevzner. 2017. "Dereplication of Peptidic Natural Products Through Database Search of Mass Spectra." Nature Chemical Biology 13 (1): 30. https://doi.org/10.1038/s41467-018-06082-8.

Quinn#, Robert A, Louis-Felix Nothias#, Oliver Vining, Michael Meehan, Eduardo Esquenazi, and Pieter C Dorrestein. 2017. "Molecular Networking as a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy." Trends in Pharmacological Sciences 38 (2): 143--54. https://doi.org/10.1016/j.tips.2016.10.011.

Scheubert, Kerstin, Franziska Hufsky, Daniel Petras, Mingxun Wang, Louis-Felix Nothias, Kai Dührkop, Nuno Bandeira, Pieter C Dorrestein, and Sebastian Böcker. 2017. "Significance Estimation for Large Scale Metabolomics Annotations by Spectral Matching." Nature Communications 8 (1): 1--10. https://doi.org/10.1038/s41467-017-01318-5.

Olivon, Florent, Pierre-Marie Allard, Alexey Koval, Davide Righi, Gregory Genta-Jouve, Johan Neyts, Cécile Apel, et al. 2017. "Bioactive Natural Products Prioritization Using Massive Multi-Informational Molecular Networks." ACS Chemical Biology 12 (10): 2644--51. https://doi.org/10.1021/acschembio.7b00413.

Nothias, Louis-Félix, Stéphanie Boutet-Mercey, Xavier Cachet, Erick De La Torre, Laurent Laboureur, Jean-François Gallard, Pascal Retailleau, et al. 2017. "Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia Semiperfoliata." Journal of Natural Products 80 (10): 2620--9. https://doi.org/10.1021/acs.jnatprod.7b00113.

Esposito, Mélissa, Shweta Nim, Louis-Félix Nothias*, Jean-François Gallard, Manpreet Kaur Rawal, Jean Costa, Fanny Roussi, et al. 2017. "Evaluation of Jatrophane Esters from Euphorbia Spp. As Modulators of Candida Albicans Multidrug Transporters." Journal of Natural Products 80 (2): 479--87. https://doi.org/10.1021/acs.jnatprod.6b00990.

Esposito, Mélissa, Louis-Félix Nothias, Pascal Retailleau, Jean Costa, Fanny Roussi, Johan Neyts, Pieter Leyssen, David Touboul, Marc Litaudon, and Julien Paolini. 2017. "Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia Pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking." Journal of Natural Products 80 (7): 2051--9. https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.7b00233.

Mingxun, Wang, Jeremy J Carver, Vanessa V Phelan, Laura M Sanchez, Neha Garg, Yao Peng, Don Duy Nguyen, et al. 2016. "Sharing and Community Curation of Mass Spectrometry Data with Global Natural Products Social Molecular Networking." Nature Biotechnology 34 (8): 828--37. https://doi.org/10.1038/nbt.3597.

Nothias, Louis-Felix, Rob Knight, and Pieter C Dorrestein. 2016. "Antibiotic Discovery Is a Walk in the Park." Proceedings of the National Academy of Sciences 113 (51): 14477--9. https://doi.org/10.1073/pnas.1618221114.

Petras#, Daniel, Louis-Felix Nothias#, Robert A Quinn, Theodore Alexandrov, Nuno Bandeira, Amina Bouslimani, Gabriel Castro-Falcón, et al. 2016. "Mass Spectrometry-Based 3D Cartography Displays the Chemistry Associated with Modern Human Habitats." Analytical Chemistry 88 (22): 10775. https://doi.org/10.1021/acs.analchem.6b03456.

Esposito#, M, Louis-Felix Nothias-Scaglia#, H Nedev, JF Gallard, P Leyssen, P Retailleau, J Costa, et al. 2016. "Euphorbia Dendroides Latex as Source of Jatrophane Esters: Their Isolation, Structural Analysis, Conformational Study and Anti-Chikv Activity." Journal of Natural Products 79 (11): 2873--82. https://doi.org/10.1021/acs.jnatprod.6b00644.

Esposito, M, Louis-Felix Nothias-Scaglia, P Leyssen, F Roussi, D Touboul, J Costa, J Paolini, and M Litaudon. 2016. "Targeting New Anti-Chikv Diterpenoids from Two Corsican Euphorbia Species Using Molecular Networking." Planta Medica 82. http://doi.org/10.1055/s-0036-1596248.

Nothias, Louis-Felix, Ivan Protsiuc, T Alexandrov, R Knight, A Brunelle, D Touboul, and PC Dorrestein. 2016. "3D-Plant2cells ProjectSpatial Metabolomic, Spatial Metagenomic, and 3D Mass Spectrometry Imaging, to Explore the Impact of Pesticides on Plant Metabolome and Microbiota." In Planta Medica. Vol. 82. Georg Thieme Verlag KG. https://bit.ly/2wwyF2p.

Nothias-Scaglia, Louis-Felix, Vincent Dumontet, Johan Neyts, Fanny Roussi, Jean Costa, Pieter Leyssen, Marc Litaudon, and Julien Paolini. 2015. "LC-Ms2-Based Dereplication of Euphorbia Extracts with Anti-Chikungunya Virus Activity." Fitoterapia 105: 202--9. https://doi.org/10.1016/j.fitote.2015.06.021.

Nothias-Scaglia, Louis-Felix, Christophe Pannecouque, Franck Renucci, Leen Delang, Johan Neyts, Fanny Roussi, Jean Costa, Pieter Leyssen, Marc Litaudon, and Julien Paolini. 2015. "Antiviral Activity of Diterpene Esters on Chikungunya Virus and Hiv Replication." Journal of Natural Products 78 (6): 1277--83. https://doi.org/10.1021/acs.jnatprod.5b00073.

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